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Clinical Papers

To help you stay up to date on the latest advancements in aesthetic medicine, we regularly review the latest literature and discuss the most interesting and relevant techniques and clinical studies here in our Clinical Papers section.

Clinical Papers
Two case studies of a laser-resistant port-wine stain (PWS) previously treated with pulsed dye laser and maximum spot size of 10 mm. Marked lightening of the PWS with no epidermal injury was observed in a skin type III male and laser-resistant PWS improvement in a skin type IV male, following 2 monthly Vbeam Prima treatments with the large 15 mm spot size.
Clinical Papers
28 women with photodamage underwent a picosecond laser treatment with the Resolve 1064 nm handpiece, using low energy fluence of 1.1 J/cm2 or high energy treatment (2.1 J/cm2). High energy group showed significant improvement with a more pronounced effect on facial skin than low energy treatments. Histopathological examination of biopsies at 3 weeks’ post-treatment showed a marked elevation in collagen type III expression antibodies in the high fluence group.
Clinical Papers
18 postmenopausal women with atrophic vaginitis received 3 monthly CO2RE Intima laser treatments to the vulva and vaginal canal. Restoration of normal or near‐normal vaginal health index (VHI) following treatment in the recently menopausal (1–3 years) cohort was significantly greater than that of the >3 years postmenopausal population. Female Sexual Function Index (FSFI) was significantly improved at the 12-month follow-up.
Clinical Papers
20 subjects were randomly assigned to split-face treatment with PicoWay Resolve (532/1064 nm picosecond lasers) treatment to one side of the face and 1927 nm fractionated thulium fiber laser (TFL) to the contralateral side. Blinded, non‐treating evaluator assessments of photodamage at 6-month follow-up showed statistically significant improvements in photodamaged skin in both treatment groups, but with less downtime associated with Resolve treatments.
Clinical Papers
Retrospective study of 69 subjects with erythema from various skin conditions including telangiectasia, cherry angioma, striae, and rosacea. 31 patients were pretreated with topical anesthetics before 1-6 Vbeam treatments, while 38 patients had no pretreatment anesthetic. Improvement was observed in both groups by blinded dermatologists, with no significant difference between groups.
Clinical Papers
This study examined several males and females who had tattoos removed thanks to treatment from a 730 nm titanium-sapphire laser-pumped laser. A blind assessment showed clearance in varying degrees for six different colors of pigments without scarring or pigmentary alteration.
Clinical Papers
Two Korean females with multiple freckles on the face (Case 1) and melasma, freckles, lentigines and erythema (Case 2) underwent a single PicoWay 730 nm picosecond laser treatment and were evaluated at 6 weeks post‐treatment. Independent evaluation of global assessment, by 2 dermatologists, indicated excellent response (75–94% lightening) for Case 1 and good response (50–74% lightening) for Case 2.
Clinical Papers
Retrospective chart and photographic review of 233 patients treated with PicoWay and Resolve handpieces for nontattoo indications. Blinded review of treatment outcome showed that every type of skin lesion exhibited improvement; epidermal nevi exhibited the greatest improvement with treatment and acne scarring the least improvement.
Clinical Papers
Biopsy samples from East Asian subjects were treated with either a Resolve 532-nm handpiece or a Resolve 1064-nm handpiece and examined for laser-induced optical breakdowns and intradermal laser-induced cavitations. Superficial, intra-epidermal LIOBs were seen in skin treated with higher laser energies. Deep, intradermal LICs were seen in skin treated at lower energies.
Clinical Papers
25 women with moderate, severe and very severe symptoms of stress urinary incontinence (SUI) or mixed urinary incontinence (MUI) received 3 monthly CO2RE Intima laser treatments to the vaginal canal. Statistically significant improvement in ICIQ-UI scores and Sandvik index was reported following the 1st treatment. Total FSFI score demonstrated a statistically significant increase following treatments, with the highest score in the desire domain.
Clinical Papers
A retrospective study of several male and female patients with ET rosacea treated with both PDL treatments and daily oxymetazoline cream. A blind evaluation by board-certified dermatologists showed the overwhelming majority of subjects achieved at least a two-point clearance in telangiectasias.