Treatment of the skin manifestations of hereditary hemorrhagic telangiectasia with pulsed dye laser

Women and men with cutaneous facial lesions of HHT were treated with a Vbeam at three-month intervals until clinical improvement was achieved. Excellent clearance occurred after a mean of 2.6 treatments.

PubMed Reference:Halachmi S, Israeli H, Ben-Amitai D, Lapidoth M. Lasers Med Sci. 2014 Jan.

Study Details:

  • 8 patients (5 males, 3 females, Fitzpatrick Skin Type II-IV) with cutaneous facial lesions of hereditary hemorrhagic telangiectasia (HHT).
  • Vbeam parameters: pulse duration of 10ms, spot sizes of 5-7 mm, energy fluency 9.5-11 J/cm2, 1.5msec pulses and DCD cooling (30msec spray/20msec delay).
  • All lesions received 2 stacked pulses during treatment.
  • Treatments repeated at 3-month intervals until satisfactory clinical improvement achieved.
  • 2 independent physicians graded photographs, using a 5-point scale.

Study Results:

  • All patients exhibited excellent (75-100%) clearance after a mean of 2.6 treatments (range 1-8).
  • In comparison, a control group of patients with non-HHT facial telangiectasia required a mean of 1.9 (range 1-5; p< 0.05) treatments.
  • No adverse events were reported in either group.