Therapeutic efficacy of long-pulsed 755-nm alexandrite laser for seborrheic keratoses

PubMed Reference:Kim YK, Kim DY, Lee SJ, et al. J Eur Acad Dermatol Venereol. 2014 Aug.

Study Details:

  • 13 Korean patients (11 males, 2 females, mean age 59.3 years, range 33-77; Fitzpatrick skin types III and IV) with 216 seborrheic keratoses
  • 1 or 3 sessions of long-pulsed 755-nm alexandrite laser (GentleMax) with 35 J/cm2, 6-mm spot size, a 3-msec pulse width and 1-2 passes, DCD cooling
  • Blinded evaluation (3 dermatologists) at 2 months after the last treatment, using a 1- 4 severity grading score.

Study Results:

  • Mean objective improvement score of 3.4±0.7 (Grade 3=Marked Improvement)
  • Type of lesion impacted number of treatment sessions needed, in particular, popular lesions needed more treatment than macular lesions 
  • Objective improvement score was not affected by the type of the seborrheic keratosis
  • Most of the lesions became crusted within a few days after the laser treatment and spontaneously peeled off within 7 days.