Randomized, blinded, 3-arm clinical trial assessing optimal temperature and duration for treatment with minimally invasive fractional radiofrequency

In this study, subjects were allocated to three study arms and underwent single-pass fractional RF Profound treatment. Three physicians assed digital photos to determine significantly positive results.

PubMed Reference:Alexiades M, Berube D. Dermatol Surg. 2015 May;41(5):623-32.

Study Details:

  • 15 subjects allocated to 3 study arms (Table 1)
  • Single-pass fractional RF (FRF) Profound treatment
  • 3 physicians - blinded assessment of digital photos

Study Results:

  • Optimal treatment settings of 67°C and 3-4 seconds confirmed
  • 100% response rate for rhytides (Fitzpatrick Wrinkle Scale) at 67°C
  • Continued improvement up to 6 months post-treatment
  • May yield>37% improvement of lower surgical face-lift
  • Simplicity, 32-minute average duration & safety profile (no significant adverse events)
    • important in cost-benefit analysis compared to face-lift