Skip to main content
Clinical Papers

Histological Characterization of Age-Related Skin Changes Following the Use of Picosecond Laser: Low Versus High Energy


28 women with photodamage underwent a picosecond laser treatment with the Resolve 1064 nm handpiece, using low energy fluence of 1.1 J/cm2 or high energy treatment (2.1 J/cm2). High energy group showed significant improvement with a more pronounced effect on facial skin than low energy treatments. Histopathological examination of biopsies at 3 weeks’ post-treatment showed a marked elevation in collagen type III expression antibodies in the high fluence group.

Reference: Kirsanova LV, Araviyskaya ER, Rybakova MG, et al. Dermatol Ther 2020 May 21.  

Study Details:

  • 28 women (mean age 51.3 years, range 36 – 60) with signs of age-related photodamage underwent a picosecond laser treatment with the Resolve 1064 nm handpiece
  • Group 1 subjects (n=14) received 4 passes in a horizontal and vertical pattern with low energy fluence of 1.1 J/cm2, while Group 2 (n=14) received high energy treatment (2.1 J/cm2)
  • Clinical assessment included skin turgor and texture, wrinkle severity and pore openings
  • Histological analysis was performed by 2 independent dermatopathologists

Study Results:

  • Group 2 showed significant improvement with a more pronounced effect on facial skin than in Group 1
  • Histopathological examination demonstrated minimal changes in the epidermis and dermis in Group 1 compared to more pronounced morphological changes in Group 2, with a marked elevation in collagen type III expression antibodies in the high fluence group