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Clinical Papers

Efficacy of the Use of Fractional CO2RE Intima Laser Treatment in Stress and Mixed Urinary Incontinence


25 women with moderate, severe and very severe symptoms of stress urinary incontinence (SUI) or mixed urinary incontinence (MUI) received 3 monthly CO2RE Intima laser treatments to the vaginal canal. Statistically significant improvement in ICIQ-UI scores and Sandvik index was reported following the 1st treatment. Total FSFI score demonstrated a statistically significant increase following treatments, with the highest score in the desire domain. 

Reference: Palacios S, Ramirez M. Eur J Obstet Gynecol Reprod Biol 2020 Jan;244:95-100.

Study Details:

  • 25 women aged 35–68 years who presented with moderate, severe and very severe symptoms of SUI* or MUI*, based on Sandvik index and ICIQ-UI scores were treated
  • 3 monthly CO2 treatments with 2 laser passes: first to the vaginal canal with an energy of 70 mJ and a fluence of 396 J/cm2, followed by a second pass covering an angle of 120° of the anterior area (from 10 to 2 o’clock) to reinforce the bladder region 
  • Validated ICIQ questionnaire and Female Sexual Function Index (FSFI) scores evaluated after each treatment

Study Results:

  • Statistically significant improvement in ICIQ-UI scores and Sandvik index after the 1st treatment (p = 0.025); increasing to (p< 0.001) after the 2nd and 3rd treatments
  • Total FSFI score demonstrated a statistically significant increase (p<0.05) with the highest score in the desire domain
  • Side effects limited to 2 cases of vaginal candidiasis