25 women with moderate, severe and very severe symptoms of stress urinary incontinence (SUI) or mixed urinary incontinence (MUI) received 3 monthly CO₂RE Intima laser treatments to the vaginal canal. Statistically significant improvement in ICIQ-UI scores and Sandvik index was reported following the 1st treatment. Total FSFI score demonstrated a statistically significant increase following treatments, with the highest score in the desire domain. 

Reference: Palacios S, Ramirez M. Eur J Obstet Gynecol Reprod Biol 2020 Jan;244:95-100.

Study Details:

• 25 women aged 35–68 years who presented with moderate, severe and very severe symptoms of SUI* or MUI*, based on Sandvik index and ICIQ-UI scores were treated
• 3 monthly CO₂ treatments with 2 laser passes: first to the vaginal canal with an energy of 70 mJ and a fluence of 396 J/cm², followed by a second pass covering an angle of 120° of the anterior area (from 10 to 2 o’clock) to reinforce the bladder region 
• Validated ICIQ questionnaire and Female Sexual Function Index (FSFI) scores evaluated after each treatment

Study Results:

• Statistically significant improvement in ICIQ-UI scores and Sandvik index after the 1st treatment (p = 0.025); increasing to (p< 0.001) after the 2^nd and 3^rd treatments
• Total FSFI score demonstrated a statistically significant increase (p<0.05) with the highest score in the desire domain
• Side effects limited to 2 cases of vaginal candidiasis