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Clinical Papers

A randomized side-by-side study comparing alexandrite laser at different pulse durations for port wine stains


PubMed Reference: Carlsen BC, Wenande E, Erlendsson AM, et al. Lasers Surg Med. 2017 Jan;49:97-103. 

Study Details:

  • 16 adults (6 men, 10 women) aged 27–78 (mean 50.3) with Fitzpatrick Skin Type I-III
  • 14 PWS previously PDL-treated with deep red (n = 4), purple macular (n = 5) and purple hypertrophic (n = 7) PWS
  • PWS subdivided to 3 test areas randomized to 755nm Alex laser (GentleMax): 8mm spot size (DCD 60/40); pulse durations of 3ms (fluence 40–65 J/cm2), 5ms (fluence 45–70 J/cm2) or 10ms (fluence 50–80 J/cm2) - 4th test spot untreated control 
  • PWS clearance evaluated on a scale of 0=no response to 4=excellent response (75–100% clearance).

Study Results:

  • Alex laser at 3, 5, and 10 ms pulse durations demonstrated significant clearance compared to untreated controls (P < 0.001)
  • 3ms pulse duration had higher clearance rates than 5ms or 10ms and a better safety profile.