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Clinical Papers

Evaluation of the Safety and Efficacy of the Dual Wavelength Picosecond Laser for the Treatment of Benign Pigmented Lesions in Asians


PicoWay 532nm and 1064nm treatments were applied to subjects with benign pigmentary disorders. The majority of patients saw good to excellent responses with improvement being more pronounced in freckles and lentigines than melasma.

PubMed Reference: Kung KY, Shek SY, Yeung CK, Chan HH. Lasers Surg Med. 2019 Jan;51:14-22.

Study Details: 

  • 12 female subjects (mean age 47.3 years, range 37-57; Fitzpatrick skin types III to IV) with benign pigmentary disorders
  • PicoWay 532nm and 1064nm treatments at 2 to 6-week intervals
  • Blinded evaluation of % clearance using clinical photography
  • Follow-ups at 4, 8, and 12 weeks after the last treatment session

Study Results: 

  • Over 90% of all pigments achieved good or excellent response (>50% lightening) at both 1-month and 2-month follow-ups
  • Clinical improvement was better for freckles and lentigines than melasma
  • Lower rate of PIH induced by picosecond laser is explained by a much more targeted photomechanical and lesser photothermal effects than Q-switched laser