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Clinical Papers

Treatment of poikiloderma of Civatte using a redesigned pulsed dye laser with a 15 mm diameter treatment spot


Male and female subjects of varying skin types were treated for POC with the Vbeam Prima. Blinded physician reviewers found a significant rate of success without hypo/hyperpigmentation or scarring.

PubMed Reference: Bernstein EF, Schomacker K, Paranjape A, Jones CJ. Lasers Surg Med. 2018 Nov 27. 

Study Details: 

  • 17 subjects (10 females, 7 males; mean age 55±4 years, range 47-61 years; Fitzpatrick Skin Types I-IV) with Poikiloderma of Civatte (POC) completed the study.
  • Vbeam Prima parameters for 4 monthly treatments:
    • 15mm with mean fluence 5-5.7 J/cm2 , pulse repetition rate of 1.5 Hz.,1.5 ms pulse duration
    • DCD cooling (40ms cooling/20ms delay).
  • 3 blinded physician reviewers graded improvement on a 11-point scale of from 0 to 100%improvement in 10% increments.

Study Results: 

  • Blinded evaluation success rate of 94% (16/17 post-treatment images correctly identified).
  • Significant improvement (P<0.0001) with mean score of 4.9, corresponding to 49.2%improvement.
  • No or mild transient erythema, purpura or edema following treatment.
  • No hypo-/hyperpigmentation or scarring.