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Clinical Papers

Efficacy of the long-pulsed 1064-nm neodymium: yttrium aluminum-garnet laser (LPND) (rejuvenation mode) in the treatment of papulopustular rosacea (PPR): A pilot study of clinical outcomes and patient satisfaction in 30 cases


PubMed Reference: Lee JH, Kim M, Bae JM, et al. J Am Acad Dermatol. 2015 Aug.

Study Details:

  • 30 Korean subjects (24 females, 6 males) with Fitzpatrick Skin Types IV-V and papulopustular rosacea (PPR)
  • Group A: 22 patients with mild-to-moderate PPR treated with laser alone
  • Group B: 8 patients with severe PPR treated with laser + doxycycline (100 mg twice daily)
  • 3 full-face Nd:YAG GentleMax treatments (40 to 50 J/cm2, 50 msec pulse duration and a 10-mm spot size, DCD cooling) at 4-week intervals
  • Blinded evaluation (3 dermatologists) at 4 weeks after the last treatment, using a 4- point severity grading system for rosacea.

Study Results:

  • Excellent to good overall improvement was seen in 77.3% (17 of 22) of patients in Group A and 87.5% (7 of 8) of patients in Group B
  • Significant decrease in papule/pustule activity and improvement in erythema score.